Chlamydia pneumonia and cerebrovascular disease

J.P. Linares-Palomino, J. Gutiérrez-Fernández, C. López-Espada, E. Ros-Díe, J. Moreno-Escobar, T. Pérez, M. Rodríguez-Fernández, M.d. Maroto-Vela Original ● Views 4763 ● Downloads 151 Castellano English Português

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DOI: https://doi.org/10.33588/rn.3203.2000420

Chlamydia pneumoniae has relationship with artherosclerosis of carotid artery by seroepidemiological studies and by demonstration of the bacteria in ateromata. We made a casecontrol study to know the seroprevalence of chronic infection of C. pneumoniae and the presence of the bacteria in arterial biopsies.

PATIENTS AND METHODS. The cases group was constituted by 26 patients undergoing carotid surgery. In the control group there were 50 patients without atherosclerosis and who underwent removal of their varicose veins. There were matched for sex, age and smoking. We obtained serum samples to determinate IgG antibodies against MOMP by MIF and ELISA. In the cases group, we got the arterial biopsies from carotid artery, and from pudendal arteries in control group. We determinated chlamydial DNA on the biopsies by heminested PCR (primers: HL1, HM1, HR1). We measured fibrinogen in both groups.

RESULTS. By MIF technique, the seroprevalence was (IgG>1:32) 69,23% cases versus 24% controls (OR: 7.12. CI: 2.4720.48). The ELISA showed 76.92% of seropositivity in cases versus 16% in controls (OR: 17.5, CI: 95%:5.3557.23). The DNA of C. pneumoniae was found in 18 cases and 6 controls, (p< 0.0001, c2). We did not find any relationship between fibrinogen levels and groups. CONCLUSION. We think that there is a relationship between chronic infection with C. pneumoniae and carotid atherosclerosis.

Keywords Antibody Atherosclerosis Carotid stenosis Casecontrol studies Polymerase chain reaction Classified in Patología vascular

Chlamydia pneumonia and cerebrovascular disease

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