Original

Correlation between the expression of proinflammatory cytokines and matrix metalloproteinases in the acute phase of an ischemic stroke

J. Montaner, J. Álvarez-Sabín, G. Barberá, A. Anglés, C. Molina, S. Abilleira, J.F. Arenillas-Lara, P. Chacón, J. Monasterio [REV NEUROL 2001;33:115-118] PMID: 11562868 DOI: https://doi.org/10.33588/rn.3302.2001142

OPEN ACCESS

Volumen 33 | Number 02 | Nº of views of the article 5.542 | Nº of PDF downloads 172 | Article publication date 16/07/2001

Download PDF Castellano Citation Search in PubMed

Share in:

Go to another issue

ABSTRACT

INTRODUCTION Proinflammatory cytokines are the main responsible for the onset of postischemic inflammatory cascade. Recently, the deleterious effect of matrix metalloproteinases (MMPs) in the acute phase of stroke has been described. Animal models suggest a link between both families. OBJECTIVE. We aimed to investigate possible relations between the MMP overproduction and proinflammatory cytokine expression after human ischemic stroke.

PATIENTS AND METHODS From all consecutive stroke patients attended during a 10 months period, we selected and prospectively studied those presenting as a cardioembolic stroke involving the MCA territory. MMP-9, MMP-2 and IL-6 were serially measured by means of ELISA at study entry and at 12, 24 and 48 hours after symptoms onset.

RESULTS A total of 39 patients were studied. A positive correlation was found between mean expression of both MMPs and IL-6 (r= 0.33, p= 0.040 for MMP-2 y r= 0.45, p= 0.004 for MMP-9). From all measured timepoints, the best obtained correlation was that of MMP-9 with IL-6 at 24 hours (r= 0.418, p= 0.010). At 24 h a peak value of IL-6 was observed. Baseline MMP-2 and MMP-9 levels showed a trend to correlate with that peak of IL-6 (r= 0.329, p= 0.061 for MMP-2 y r= 0.325, p= 0.061 for MMP-9). CONCLUSION. MMP expression correlates with the inflammatory cascade activation after acute cardioembolic stroke. KeywordsEmbolism Interleukin-6 Matrix metalloproteinases Stroke CategoriesPatología vascular

FULL TEXT (solo disponible en lengua castellana / Only available in Spanish)

Acceso directo al último número

Último Podcast

Original

Correlation between the expression of proinflammatory cytokines and matrix metalloproteinases in the acute phase of an ischemic stroke

¡CONVIÉRTASE EN USUARIO PREMIUM DE NEUROLOGIA.COM!

Al hacerse premium, está apoyándonos para que Revista de Neurología siga siendo uno de los referentes de habla hispana en la difusión del conocimiento en neurociencias. ¡Gratuita tanto para autores como para todos los usuarios de la web!