Gabapentina

Safety and tolerability of gabapentin

C. Viteri [REV NEUROL 2002;34:292-295] PMID: 12022084 DOI: https://doi.org/10.33588/rn.3403.2001526

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Volumen 34 | Number 03 | Nº of views of the article 5.082 | Nº of PDF downloads 408 | Article publication date 01/02/2002

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ABSTRACT

OBJECTIVE. To review the information available regarding the safety and tolerability of gabapentin (GBP) in the treatment of epilepsy.

PATIENTS AND METHODS We reviewed the reports in the literature on the safety, adverse effects and tolerance of GBP as treatment , used as monotherapy or associated with other drugs, in epilepsies in patients of all age groups, including children, adults and the elderly.

RESULTS All published studies confirm that GBP is a well-tolerated drug when used for monotherapy or associated with other antiepileptic drugs. The commonest adverse effects seen were somnolence, fainting, ataxia, nystagmus, tremor and headache. However, their incidence was low and intensity mild. There was no clear relationship between the dose given and appearance of side-effects, except for fainting and somnolence.

CONCLUSIONS GBP is a drug which is free of unwanted side-effects. Its safety and tolerability profile is excellent for treatment of simple and complex partial crises, with or without generalization in epileptic patients of all ages. KeywordsAdverse effects Epilepsy Gabapentin Partial crises Safety Tolerability CategoriesEpilepsias y síndromes epilépticos

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Gabapentina

Safety and tolerability of gabapentin