Nota Clínica

Disturbances of neuroblast migration and amniocentesis. An under-diagnosed problem?

J.M. Prats-Viñas, C. Garaizar, M.J. Martínez-González, A. García-Ribes [REV NEUROL 2003;36:33-36] PMID: 12577210 DOI: https://doi.org/10.33588/rn.3601.2002365

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Volumen 36 | Number 01 | Nº of views of the article 5.436 | Nº of PDF downloads 359 | Article publication date 01/01/2003

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ABSTRACT

INTRODUCTION Performing amniocentesis between the fourth and sixth months of gestation is a widespread practice. However, it can entail serious consequences, apart from the loss of the foetus, such as injuries to the developing central nervous system. CASE REPORTS. Over the past few years we have dealt with four patients who were carriers of a focal disturbance of neuroblast migration, which could have its origins in amniocentesis. Two patients displayed mental retardation and difficult-to-treat epilepsy, while the other two only presented hemiparesis. In two cases the right hemisphere of the brain was affected. One of them also presented extracranial brain tissue, which was possibly extruded during the accidental puncture of the skull.

CONCLUSIONS Despite its being rarely mentioned in the literature, a direct or indirect attack on the brain during diagnostic amniocentesis is a possibility that must be borne in mind when considering the use of this technique KeywordsCongenital hemiplegia Difficult-to-treat epilepsy Focal disturbances of neuroblast migration CategoriesEpilepsias y síndromes epilépticos

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Nota Clínica

Disturbances of neuroblast migration and amniocentesis. An under-diagnosed problem?