Original

Gender has a strong modulating effect on the risk of Alzheimer’s disease conferred by the apolipoprotein E gene in the population of the Canary Islands, Spain

M.C. Déniz-Naranjo, C. Muñoz-Fernández, M.J. Alemany-Rodríguez, M.C. Pérez-Viéitez, J. Irurita-Latasa, R. Suárez-Armas, M.P. Suárez-Valentín, F. Sánchez-García [REV NEUROL 2004;38:615-618] PMID: 15098180 DOI: https://doi.org/10.33588/rn.3807.2003264

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Volumen 38 | Number 07 | Nº of views of the article 5.171 | Nº of PDF downloads 322 | Article publication date 01/04/2004

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ABSTRACT

OBJECTIVES. Apolipoprotein E (ApoE) gen has been found to confer risk for Alzheimer disease in every population studied. We are interested in analyzed the exonic variants and the promoter polymorphisms in our Canary population. Subjects and methods. By means of PCR-RFLP analysis of DNA from patients (NINCS-ADRDA criteria) and controls (cognitive state CAMCOG test measured) we analyzed the known exonic and promoter polymorphism of ApoE gen.

RESULTS We have found an association of Alzheimer disease risk based on exonic variants of ApoE gen, with a clear cut dose-effect on susceptibility and no risk conferred by the promoter polymorphisms. Age at onset are not affected by variants of ApoE gen, and patients gender strongly modulate the disease susceptibility. CONCLUSION. We have found in our Canary population an association between Alzheimer disease with exonic variants of ApoE gen with a strong modulation by the patients gender. KeywordsAlzheimer disease Canary Islands Exonic ApoE polymorphisms Promoter ApoE polymorphisms Spain CategoriesDemencia Neurodegeneración

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Original

Gender has a strong modulating effect on the risk of Alzheimer’s disease conferred by the apolipoprotein E gene in the population of the Canary Islands, Spain