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Muscle regeneration following glycerol injection mimic that of mdx-mice degenerative-regenerative groups

M. Roig-Quilis, J. Roma, M. Marotta, Y. Sarria, A. Fargas [REV NEUROL 2004;38:1101-1108] PMID: 15229820 DOI: https://doi.org/10.33588/rn.3812.2004144

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Volumen 38 | Number 12 | Nº of views of the article 8.757 | Nº of PDF downloads 376 | Article publication date 16/06/2004

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ABSTRACT

INTRODUCTION In recent years several authors have proposed that muscle pathological changes in humans with dystrophin disorders and in mdx-mice are the result of regeneration attempts of this tissue subjected to constantly repeated bouts of necrosis.

AIM We compared morphological aspects of degenerative-regenerative groups observed in the mdx-mice with the regenerative phases that follow an intramuscular injection of 30mL glycerol.

MATERIALS AND METHODS Gastrocnemius samples from mdx-mice, 1 to 5 months old and from glycerol injected C57Bl10/ScSn mice, 4 to 8 months old, were processed and analyzed in parallel.

RESULTS We were able to recognize degenerative-regenerative group stages in the mdx-mice that closely matched the anomalies found 1, 2, 3, 4-5, 7 and 21-28 days following the injection with glycerol. CONCLUSION. This study reinforces the hypothesis that muscle pathologic abnormalities of mdx-mice are the result of chronic muscle necrosis-regeneration. Morphologic mdx-mice degenerative-regenerative group staging will be a helpful tool for future investigation of muscle regeneration. KeywordsIntramuscular injection Muscle regeneration Muscular dystrophy CategoriesNervios periféricos, unión neuromuscular y músculo Neurodegeneración

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Original

Muscle regeneration following glycerol injection mimic that of mdx-mice degenerative-regenerative groups