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Diabetes mellitus as a risk factor for dementia in the Mexican elder population

S. Mejía-Arango, C. Zúñiga-Gil [REV NEUROL 2011;53:397-405] PMID: 21948010 DOI: https://doi.org/10.33588/rn.5307.2010628

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Volumen 53 | Number 07 | Nº of views of the article 8.793 | Nº of PDF downloads 1.125 | Article publication date 01/10/2011

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ABSTRACT

INTRODUCTION Diabetes and dementia are growing problems throughout the world and especially in developing countries.

AIM To determine the risk of developing dementia in subjects with type 2 diabetes mellitus.

PATIENTS AND METHODS Diabetic elders free of dementia from the Mexican Health and Aging study, a prospective community-based cohort research were followed after two years. Socio-demographic factors, comorbid conditions and type of diabetes treatment were analyzed in subjects who become demented.

RESULTS At baseline, 749 participants (13.8%) had diabetes mellitus. During the follow-up period (mean: 2.02 years; range: 1-3 years), 306 of 749 persons with diabetes mellitus developed dementia, yielding a relative risk (RR) of 2.08 (95% confidence interval, 95% CI = 1.59-2.73). The effect was strongest in persons aged 80 years or older with a RR of 2.44 (95% CI = 1.46-4.08), men had a greater relative risk than women (RR = 2.25; 95% CI = 1.46-3.49 vs. RR = 1.98; 95% CI = 1.08-1.11) and subjects with low education (< 7 years of schooling) had a significant RR while those with higher education didn’t. Individuals treated with insulin where at highest risk of dementia (RR = 2.83; 95% CI = 1.58-5.06). Hypertension (RR = 2.75; 95% CI = 1.86-4.06) and depression (RR = 3.78; 95% CI = 2.37-6.04) where the two comorbidities which increased the risk of dementia.

CONCLUSIONS Subjects with diabetes mellitus have an increased risk of developing dementia. Sociodemographic factors and other comorbidities highly prevalent in the Mexican population contribute to the diabetes-dementia association. KeywordsCognition Dementia Depression Diabetes mellitus Hypertension Risk CategoriesDemencia Neuropsiquiatría

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Diabetes mellitus as a risk factor for dementia in the Mexican elder population

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