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Gastroparesis and other gastrointestinal symptoms in Parkinson’s disease

D. Santos-García, T. de Deus-Fonticoba, C. Tejera-Pérez, I. Expósito-Ruiz, E. Suárez-Castro, P. Carpintero, M. Macías-Arribi [REV NEUROL 2015;61:261-270] PMID: 26350777 DOI: https://doi.org/10.33588/rn.6106.2015203

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Volumen 61 | Number 06 | Nº of views of the article 13.522 | Nº of PDF downloads 1.125 | Article publication date 16/09/2015

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ABSTRACT

Different gastrointestinal symptoms, such as excessive salivation, deterioration and other disorders affecting the teeth, dysphagia, gastroparesis, gastroesophageal reflux, constipation, difficult defecation or loss of weight are frequent events in all the stages of the development of Parkinson’s disease and affect at least a third of the patients. These symptoms reflect the dysfunction of the enteric nervous system, and the stomach is one of the organs where alpha-synuclein is first deposited. Other factors, such as the dysfunction of structures in the central nervous system like the dorsal motor nucleus of the vagal nerve, hormonal factors or secondary effects deriving from the consumption of antiparkinsonian drugs, are involved in its origin. The present article offers a detailed review of the epidemiological, pathophysiological, clinical and therapeutic management aspects of the different gastrointestinal symptoms in Parkinson’s disease. KeywordsConstipation Dysphagia Enteric nervous system Gastroparesis Parkinson’s disease Sialorrhea CategoriesNeurodegeneración Trastornos del movimiento

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Gastroparesis and other gastrointestinal symptoms in Parkinson’s disease