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Reversible alterations in the neuroimages associated with vigabatrine treatment in infants with epileptic spasms

M.A. Fernández-García, J.J. García-Peñas, H. Gómez-Martín, E. Sebastián-Pérez, E. García-Esparza, S. Sirvent-Cerdá [REV NEUROL 2017;64:169-174] PMID: 28169412 DOI: https://doi.org/10.33588/rn.6404.2016157

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Volumen 64 | Number 04 | Nº of views of the article 10.837 | Nº of PDF downloads 298 | Article publication date 16/02/2017

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ABSTRACT

INTRODUCTION Vigabatrin (VGB) is a first-line drug for the treatment of infantile spasms. Recently, several reports claim the existence of abnormalities in magnetic resonance imaging (MRI) (particularly affecting basal ganglia, and visible in T2 and diffusion sequences) in infants with spasms that were receiving high doses of VGB (> 100 mg/kg/day), which appear to be reversible after withdrawal of treatment. CASE REPORTS. We present two cases with an epileptic encephalopathy in the first year of life and seizures consisting of infantile spasms. Both were treated with several antiepileptic drugs, including VGB up to a maximum dosage of 200 mg/kg/day. At the age of 11 and 28 months, respectively, MRI images showed marked signal hyperintensities on T2-sequences on bilateral globus pallidus, thalamus, posterior portion of the brainstem and dentate nuclei, also visible on diffusion sequences. Both had previous unaltered MRI studies. After excluding an underlying metabolic disease, VGB withdrawal is decided, appreciating the reversibility of those lesions in a prospective MRI study, three months later.

CONCLUSIONS We must consider and carefully evaluate findings on brain MRI in infants receiving VGB at high doses for treatment of spasms. The apparent cytotoxic effect on basal ganglia could simulate metabolic/mitochondrial diseases. By knowing this effect of VGB and its typical MRI features, unnecessary testing can be avoided in young infants with epileptic encephalopathies, including complex procedures like muscle biopsy or a new metabolic screening. KeywordsHyperintensity in the basal ganglia Infantile spasms Magnetic resonance Refractory epilepsy Vigabatrine Wests syndrome CategoriesEpilepsias y síndromes epilépticos Neuroimagen Trastornos del movimiento

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Nota Clínica

Reversible alterations in the neuroimages associated with vigabatrine treatment in infants with epileptic spasms