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Factors related with post-surgical complications in elderly patients with glioblastoma multiforme

M. Martín-Risco, V. Rodrigo-Paradells, S. Olivera-González, C.M. del Río-Pérez, L. Bances-Flórez, J.B. Calatayud-Pérez, F.J. Villagrasa-Compaired [REV NEUROL 2017;64:162-168] PMID: 28169411 DOI: https://doi.org/10.33588/rn.6404.2016246

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Volumen 64 | Number 04 | Nº of views of the article 6.455 | Nº of PDF downloads 111 | Article publication date 16/02/2017

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ABSTRACT

INTRODUCTION Glioblastoma multiforme is the most frequent malignant tumour of the central nervous system, and its incidence reaches 80% in those over 50 years of age. Life expectancy has increased in the population in recent times and an analysis of the post-surgical complications affecting elderly patients is of great importance for a correct surgical indication. AIMS. To analyse the factors related with post-surgical complications in elderly patients.

PATIENTS AND METHODS A sample of 88 patients diagnosed with glioblastoma multiforme between 31 and 78 years of age was analysed retrospectively. The variables taken into consideration in the study were: personal medical history, age, functional status, pre-anaesthetic status, tumour characteristics, type of surgery and post-surgical complications.

RESULTS Age was observed to have an influence on local (p = 0.006) and systemic surgical complications (p = 0.034), and on the Clavien-Dindo scale (p = 0.001). Persons with a poorer functional status and cardiovascular risk presented more systemic complications (p = 0.006 and 0.044) and a lower score on the Clavien-Dindo scale (p = 0.024 and 0.025) respectively. Likewise, more local complications are found in the case of excisional procedures than in biopsies (p = 0.027). The pre-anaesthetic status and anti-haemostatic treatments were not related with such events.

CONCLUSIONS Patients over 65 years of age present a higher incidence of pathological antecedents and a poorer pre-surgical functional status. Age, cardiovascular risk, functional status and the type of surgical procedure have significantly increased the occurrence of post-surgical complications. KeywordsBrain tumor Elderly patient Malignant glioma Postoperative systemic complication Risk factor CategoriesNeurogeriatría

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Factors related with post-surgical complications in elderly patients with glioblastoma multiforme