Neurofibroma with mucus producing glands. presentation of one case and a review of the literature
Introduction. Most tumors of peripheral nerve sheaths containing glands are malignant tumors associated with Von Recklinghausen’s disease. Clinical case. A 39 year old man consulted with a tumour on a finger of the right hand, which was not painful, and was slow growing. There was no past history of neurofibromatosis. Histological study showed a tumour of the peripheral nerve sheath, a benign type of neurofibroma containing glands. Immunohistochemical techniques confirmed that it had the stroma of a Schwannoma with well-defined glandular epithelial elements. Conclusions. A neurofibroma with glands is considered to be a rare type of divergent differentiation, and of considerable interest to pathologists, since it must be differentiated from other tumoral lesions. Immunohistochemical study is very useful for this.
Caso clínico Varón de 39 años de edad que consulta por tumor en el dedo de la mano derecha, no doloroso, de crecimiento lento sin antecedentes de neurofibromatosis. El estudio histológico corresponde a un tumor de vaina nerviosa periférica benigno tipo neurofibroma, con presencia de glándulas. Las técnicas inmunohistoquímicas confirmaron la naturaleza schwannomatosa del estroma en el que se destacan elementos epiteliales glandulares bien diferenciados.
Conclusiones El neurofibroma con glándulas está considerado un tipo raro de diferenciación divergente y resulta de gran interés para el patólogo, por la necesidad de diferenciarlo de otras lesiones tumorales. Para ello es de gran utilidad el estudio inmunohistoquímico
