Introduction. Infection of the Central Nervous System by free living amebas is an unusual event, 344 cases have been reported to date. The disease becomes evident in two different clinical fashions: Primary Amebic Meningoencephalitis (PAM)causedbyNaegleriafowleriandGranulomatousAmebicEncephalitis(GAE)inducedbySpp.ofAcanthamoebaandBalamuthia.Clinical cases. The authors report three new cases from Venezuela. Case 1. 34 years old man, with a chief complaint of general malaise, headache and fever, a diagnosis of common cold was made and the patient was treated as such, he did not improve and was admitted to the hospital with deterioration of his clinical status; the patient died 10 days after the onset of his illness which was determined to be GAE produced by Balamuthia mandrillaris. Case 2. 8 years old female admitted to the hospital because of fever, headache and generalized seizures of sudden onset; neurocysticercosis was diagnosed and following improvement the patientwasdischargedandreadmittedontwooccasionsbecauseofrelapseandworseningofherillness,shedied2monthsafter theonsetofherdiseasethatwasdiagnosedbyautopsyasGAEduetoBalamuthiamandrillaris.Case3.16yearsoldmale,previously healthy, who following immersion in a water tank was admitted to the hospital because of meningeal irritation that progressed to comaanddeathina7daylapse;autopsyrevealedPAMbyNaegleriafowleri.ThetwocasesofGAEduetoBalamuthiamandrillaris occurred in apparently immunocompetent individuals, contrary to the statement that these microorganisms are opportunistic.Conclusion. We believe that neurological infection by amphizoic amebas is being underdiagnosed, probably due to ignorance regarding this pathology or because of a very low autopsy rate in most countries