Síndrome de Reye: estudio de la casuística de un hospital provincial cubano entre 1990 y 1996
Summary. Introduction. Reye's syndrome is a metabolic encephalopathy ofinfancy which is ofen fatal. Epidemiological studies have shown associated factors including having taken Aspirin for a viral ilness. Some patients with this disorder may have preexisting organic acidemia such as dicarboxylic aciduria. Objective. To study the behavior of Reye's syndrome in a group of patents during the vears 1990-1996 in a provincial paedianic hospital and review variables such as age, sex, race, prodroma ilness, previous consumption ofAspirin, hospital stay, mortaliny, diagnosis ofdicarboxylic aciduria, etc. Patients and methods. We selected vatients with Reve's svndrome seen during the period mentioned and considered the above variables, Results. All 10 patients seen with Reye's syndrome were boys. Their ages were benween 3 months and 2 years. Most (hnine) ofthe patients were Caucasian, All patients had influenza as the prodromal ilness, and all took Aspirin as an anipvretic, There was considerable variation in the length oftheir stav in hospital, In our series there was a hieh mortalitv and only two patents survived, One bov had dicarboxvlic aciduria, Conclusions. The fatal character ofReve's svndrome has been shown, as has its relation to the use o Aspirin. In our environment there seems to be a tendency for Caucasian boys to be afected
Objetivo Estudiar el comportamiento del síndrome de Reye en un grupo de pacientes durante los años 1990 a 1996 en un hospital pediátrico provincial, y revisar variables como edad, sexo, raza, enfermedad prodrómica, consumo previo de Aspirina, estadía hospitalaria, mortalidad, diagnóstico de aciduria dicarboxílica y otras.
Pacientes y métodos Se seleccionó la casuística de síndrome de Reye en el período mencionado y se analizaron las variables comentadas.
Resultados Los 10 pacientes afectados de síndrome de Reye en nuestro hospital eran varones. La edad osciló entre 3 meses y 2 años. Predominó la raza blanca, con nueve casos. Todos los pacientes presentaron gripe como enfermedad prodrómica, y todos consumieron Aspirina como antipirético. La estancia hospitalaria varió bastante de un paciente a otro. En la serie hubo una alta mortalidad, y sólo 2 niños sobrevivieron. Un niño padeció aciduria dicarboxílica.
Conclusiones Se ha comprobado la letalidad del síndrome de Reye y su relación con el consumo previo de Aspirina. Parece que existe predilección por los varones y por la raza blanca en nuestro medio
