The Madrilenian Félix Lope de Vega Carpio (1562-1635) was the first Spanish playwright. As a privileged witness to his time and with an exquisite knowledge of the human soul, he managed to portray all the social and human reality of the Golden Age in his more than 700 plays. Illnesses and those who suffer them are to be found throughout his works. Many neurological diseases, such as apoplexy, melancholy, headaches or epilepsy, appear quite often in his plays. His descriptions are accurate and the ideas about each disease reflect the knowledge that existed during his time (galenic, medieval or renaissance).

El madrileño Félix Lope de Vega Carpio (1562-1635) es el primero de los comediógrafos españoles. Testigo privilegiado de su tiempo y sensible conocedor del alma humana, supo trasladar a sus 700 obras teatrales, al menos, toda la realidad social y humana del Siglo de Oro. Enfermedades y enfermos salpican su vasta obra. Muchas de las enfermedades neurológicas, como la apoplejía, la melancolía, la cefalea o la epilepsia, aparecen con frecuencia en sus escritos. Sus descripciones son atinadas, y las ideas sobre la enfermedad reflejan los conocimientos de su época (galénicos, medievales o renacentistas).