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Lack of correlation between plasma homocysteine levels and cerebral microangiopathy in patients with transient ischemic attacks

J. Álvarez-Sabín, J. Montaner, A. Rovira, J. Turón, C. Molina, R. Malinow, S. Abilleira, A. Codina DOI: https://doi.org/10.33588/rn.3007.2000029

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Volumen 30 | Number 07 | Nº of views of the article 6.560 | Nº of PDF downloads 165 | Article publication date 01/04/2000

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ABSTRACT

Objective. The aim of this study is to evaluate cerebral MRI findings in patients with atherothrombotic transient ischemic attacks (TIA) and its correlation with plasma homocysteine (Hcy) levels. Patients and methods. A total of 62 consecutive patients with the diagnosis of TIA of atherothrombotic origin were studied. MRI examinations were performed in all patients for the evaluation of the presence of infarct and/or white matter hyperintensities (WMHI). Plasma Hcy levels were determined according to the method described by Smolin and Schneider modified. Results. Plasma Hcy levels were significantly (p< 0.036) higher in patients with MRIdetected infarcts (9.69 ± 2.06 mmol/l) compared with patients without infarcts (8.65 ± 1.7 mmol/l. There was no correlation (p< 0.33) between plasma Hcy levels and the presence or absence of WMHI seen on MRI. Conclusions. In TIA patients, plasma Hcy levels were significantly higher in patients with cerebral infarcts, but did not correlate with the presence of WMHI. Our results suggest that mild hyperhomocysteinemia would be associated with largemedium vessel rather than with small vessel disease. KeywordsCerebral microangiopathy Hyperhomocysteinemia Transient ischemic attack CategoriesPatología vascular

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Original

Lack of correlation between plasma homocysteine levels and cerebral microangiopathy in patients with transient ischemic attacks