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Factorial and discriminant analyses of neuropsychological variables in familial and sporadic late onset Alzheimer disease

M.A. Velázquez, M. Arcos-Burgos, M.E. Toro, A. Castaño, L. Madrigal, S. Moreno, N. Jaramillo, F. Lopera [REV NEUROL 2000;31:501-506] PMID: 12497374 DOI: https://doi.org/10.33588/rn.3106.2000271

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Volumen 31 | Number 06 | Nº of views of the article 5.683 | Nº of PDF downloads 672 | Article publication date 16/09/2000

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ABSTRACT

INTRODUCTION Prevalence of late onset Alzheimer’s disease (LOAD) both familial and sporadic is increasing with the raising proportion of thirdage population. There are evidences either supporting or rejecting the existence of differences in the behavior of neuropsychological variables between familial and sporadic cases of LOAD. OBJECTIVE. To identify neuropsychological variables discriminating between familial and sporadic cases of LOAD, in order to detect clinical manifestations that may provide information on the pathological process of the neurodegenerative process.

PATIENTS AND METHODS Using sequential sampling, we selected individuals affected by LOAD according to the criteria of the DSMIV and NINCSADRDA. The following neuropsychological protocol was used: CERAD, Wisconsin, Phonological Fluency, Rey’s Figure, Raven, A Cancellation Test, WAIS (Arithmetic); also used were: Global Deterioration Scale, Functional Assessment Staging of Reisberg (FAST), Barthel and Yesavage. Parametrical and nonparametrical univariate, factorial (principal components) and discriminant analyses were performed. In total, 52 patients were analyzed (average age: 74.8 years; mean age at onset of the disease: 69 years; time of disease’s evolution: 5.7 years; average of educational level: 6.4 years).

RESULTS No significant statistical differences were found in clinical or neuropsychological variables between familial and sporadic cases of LOAD. Additionally, neither variables nor models were detected discriminating significantly between them. CONCLUSION. Familial and sporadic cases of LOAD present the same clinical and neuropsychological phenotype which makes very probable that sporadic cases are low penetrance familial ones KeywordsAlzheimer’s disease Dementia Familial Alzheimer Late onset Alzheimer’s disease Neuropsychology Sporadic Alzheimer CategoriesDemencia Neurodegeneración Neurología del Lenguaje y la Comunicación Neuropediatría Neuropsicología Neuropsiquiatría Patología vascular

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Original

Factorial and discriminant analyses of neuropsychological variables in familial and sporadic late onset Alzheimer disease