Aims. The aim of this work is to review the effects of alcohol on the MMN component, to discuss its viability as a vulnerability marker for alcoholism, and to link it with the P300 component. Method. Alcohol alters the P300 and MMN components of auditory evoked potentials. In alcoholism, the alterations observed in the P300 component in risk subjects have been seen as markers of susceptibility to development of the illness. In the case of the MMN component, on the other hand, to date its viability as a vulnerability marker has only been evaluated in three studies, with varying results. While two of them found no differences, in the third and most recent it was found that risk subjects presented an increase in the amplitude of the MMN, which was interpreted as a reflection of the cortical hyperexcitability suggested by other authors and which was also reflected in the decrease in the P300 amplitude. Conclusions. The results obtained do not enable us to draw conclusions about whether the MMN component is altered in risk subjects for alcoholism. The differences in the studies that have been conducted could be due to the variations in the characteristics of the samples used or of the evaluation of the characteristics of MMN. The analysis of previous work on P300 or MMN suggests that broader, more homogeneous samples should be used in future research and that, in addition to the MMN peak, its mean amplitude in successive intervals, together with its two subcomponents should also be evaluated separately.
KeywordsAlcoholismAttentionHuman auditory systemNeurophysiological markerVulnerabilityCategoriesTécnicas exploratorias
FULL TEXT(solo disponible en lengua castellana / Only available in Spanish)
Si ya es un usuario registrado en Neurologia, introduzca sus datos de inicio de sesión.
Rellene los campos para registrarse en Neurologia.com y acceder a todos nuestros artículos de forma gratuita
¿Olvidó su contraseña? Introduzca su correo electrónico y le haremos llegar una nueva
¡CONVIÉRTASE EN USUARIO PREMIUM DE NEUROLOGIA.COM!
Al hacerse premium, está apoyándonos para que Revista de Neurología
siga siendo uno de los referentes de habla hispana en la difusión del
conocimiento en neurociencias. ¡Gratuita tanto para autores como para
todos los usuarios de la web!
Además, por convertirte en usuario premium, recibirá las siguientes ventajas:
Plaza asegurada en todos nuestros Másteres (www.ineurocampus.com)
Descuento del 5% en los cursos de “Actualización en Neurología”, la FMC que estará disponible próximamente en la web.
Descarga gratuita en formato PDF dos de las obras con más éxito publicadas por Viguera Editores:
Oromotors Disorders in childhood (M. Roig-Quilis; L. Pennington)
Manual de Neuropsicología 2ª ed. (J. Tirapu-Ustárroz; M. Ríos-Lago; F. Maestú)
El precio para hacerse Premium durante el periodo de un año es de 5€, que podrá pagar a continuación a través de una pasarela de pago seguro con tarjeta de crédito, transferencia bancaria o PayPal:
OPEN ACCESS
