Nota Clínica

Paraneoplastic ataxia associated to anti-CV2 antibodies

V. Medrano, A.P. Sempere, E. González-Escoda [REV NEUROL 2003;36:131-133] PMID: 12589599 DOI: OPEN ACCESS
Volumen 36 | Number 02 | Nº of views of the article 8.280 | Nº of PDF downloads 335 | Article publication date 16/01/2003
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ABSTRACT Artículo en español English version
INTRODUCTION Anti-CV2 antibodies are a type of paraneoplastic antibodies that interact with the cytoplasmatic antigens of a subpopulation of oligodendrocytes. They are usually associated with the presence of a small cell carcinoma. We report the case of a patient with an epidermoid carcinoma of the lung and paraneoplastic cerebellous ataxia associated with anti-CV2 antibodies. CASE

REPORT Male aged 73, ex-smoker for 10 years, with a 45 packet/year habit. He presented a 5-month-old constitutional syndrome. Altered gait with a sensation of instability. During the course of the exploration, we detected an increase in the support base, the impossibility to walk in tandem, non-exhaustible horizontal nystagmus in bilateral extreme look, and vertical when looking down, with abolition of Achilles’ reflexes. Brain MR revealed supratentorial demyelinating lesions of a probable ischemic origin. Anti-CV-2 antibodies in serum positive (anti-HU negative). Biopsy performed using bronchial brushing in the left upper lobe detected the presence of malign epithelial strain, not microcytic, cells, which are compatible with epidermoid carcinoma. DISCUSSION. Anti-CV2 antibodies have only been found in patients who have developed a neurological syndrome within the context of a neoplasia. The detection of these antibodies in serum is related with the presence of a concealed neoplasia
KeywordsAnti-CV2 antibodiesOligodendrocytesParaneoplastic neurological syndromes
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