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Can treatment associated with ticlopidine and nifedipine increase serum levels of phenobarbital?

A. Sánchez-Romero, R. García-Delgado, J.A. Durán-Quintana [REV NEUROL 2003;36:433-434] PMID: 12640596 DOI: https://doi.org/10.33588/rn.3605.2002490

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Volumen 36 | Number 05 | Nº of views of the article 4.989 | Nº of PDF downloads 97 | Article publication date 01/03/2003

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ABSTRACT

INTRODUCTION We report a case in which the association between ticlopidine, nifedipine and phenobarbital was linked with a higher than expected phenobarbital concentration in serum, which suggested a possible interaction between these drugs.

CASE REPORT A 67-year-old male who received treatment with phenobarbital, digoxin, nifedipine, ticlopidine, paroxetine and clorazepate dipotassium. The first control of the level of phenobarbital in serum was performed without any symptoms or signs of toxicity or ineffectiveness. A phenobarbital concentration in serum of 21.4 mg/L was obtained, with a serum level/dosage ratio of 16.7.

DISCUSSION The serum level/dosage ratio of phenobarbital that was found in this case is almost twice as high as expected. In the absence of other factors that can explain this finding, we believe that two drugs (ticlopidine and nifedipine) may be involved in an interaction with phenobarbital.

CONCLUSIONS The high value of the serum level/dosage ratio that was found makes it advisable to monitor the concentrations of phenobarbital in serum in treatment associated with ticlopidine or nifedipine, especially when adjusting the dosage, beginning or ending treatment with these drugs. KeywordsCytochrome P450 Nifedipine Pharmacological interaction Phenobarbital Ticlopidine

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Nota Clínica

Can treatment associated with ticlopidine and nifedipine increase serum levels of phenobarbital?