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A review of the pharmalogic treatment of migraine in children

E. Vasconcellos [REV NEUROL 2003;37:253-259] PMID: 12938057 DOI: https://doi.org/10.33588/rn.3703.2003164

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Volumen 37 | Number 03 | Nº of views of the article 6.284 | Nº of PDF downloads 2.122 | Article publication date 01/08/2003

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ABSTRACT

OBJECTIVE. To describe the efficacy and tolerability of the different medications used to treat migraine in children and adolescents. DEVELOPMENT. A literature review of the drug studies involving children and adolescents for the treatment of migraine was conducted. The treatment of migraine is divided in abortive and prophylactic. The different classes of drugs are described in respect to its efficacy and side effects. Few placebocontrolled, doubleblind studies are available in children as compared to adults for the treatment of migraine headaches. Only ibuprofen and nasal sumatriptan have been studied and shown to be effective in more than one double blind placebocontrolled study for the abortive treatment of migraine in children. Unlike the adult studies, the oral triptans tested in children have not been effective when compared to placebo. Only flunarizine has shown efficacy in more than one placebocontrolled trial for the prophylactic treatment. CONCLUSION. Most of the medications used to treat migraine in children and adolescents are well tolerated. The treatment response of migraine in children and adolescent may differ from that of adults. There seems to be a high placebo response rate in the pediatric population. Therefore, further prospective placebocontrolled studies are needed. KeywordsAdolescent Children Migraine Treatment CategoriesCefalea y Migraña Dolor Neuropediatría

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A review of the pharmalogic treatment of migraine in children