Idiopathic epilepsies: some therapeutic aspects

J. Campos-Castelló, J.M. Prats-Viñas, A. García-Ribes [REV NEUROL 2004;38:180-184] PMID: 14752722 DOI: OPEN ACCESS
Volumen 38 | Number 02 | Nº of views of the article 6.972 | Nº of PDF downloads 2.047 | Article publication date 16/01/2004
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ABSTRACT Artículo en español English version
AIMS. The purpose of this study was to determine the therapeutic approach to be used in localisation-related and generalised epilepsies and idiopathic epileptic syndromes. DEVELOPMENT. Recent literature on the subject was reviewed, as were the records on a total of 118 patients from two paediatric neurology units between the years 2000 and 2003. With regard to the localisation-related cases, the following recommendations are made: 1. Treatment with monotherapy; 2. Low doses, since any antiepileptic drug can make epilepsy worse, and more so in the case of RBEI; 3. If the seizures get worse with treatment, the doses must be reduced instead of increased; 4) Carbamazepine (CBZ) and oxcarbazepine (OXC) are first choice drugs; clobazam (CLB) is indicated in OBEI and in some atypical BPEI, in which steroids in monotherapy can occasionally prove useful; valproate (VPA) is an alternative for cases of intolerance and exacerbation, and 5. Two-year treatment and electroencephalogram (EEG) monitoring for exacerbation. As regards idiopathic generalised epilepsies: 1. VPA in monotherapy is recommended in all the forms, 48% were controlled; 18% were controlled with VPA + lamotrigine (LTG); 2. Childhood absence epilepsy is controlled up to 50% with VPA and 85% with VPA + ethosuximide (ESM); 3. LTG, CLB, topiramate (TPM) and Rivotril ® (CLN) are alternatives to be considered in all types of epilepsies and syndromes that are resistant to medication, and 4. In GCTS, VPA should be chosen in low doses in juvenile myoclonic epilepsy of Janz. KeywordsAbsence epilepsy in infancy and childhoodBenign epilepsies in infancyGeneralised clonic-tonic seizuresIdiopathic epilepsies and epileptic syndromesJuvenile myoclonic epilepsy of Janz CategoriesEpilepsias y síndromes epilépticosTécnicas exploratorias
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