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A randomised open trial comparing monotherapy with topiramate versus carbamazepine in the treatment of paediatric patients with recently diagnosed epilepsy

J.C. Reséndiz-Aparicio, E. Rodríguez-Rodríguez, J. Contreras-Bernal, H. Ceja-Moreno, E. Barragán-Pérez, S. Garza-Morales, J. Malagón-Valdez, F. Ortega-González [REV NEUROL 2004;39:201-204] PMID: 15284957 DOI: https://doi.org/10.33588/rn.3903.2004186

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Volumen 39 | Number 03 | Nº of views of the article 5.108 | Nº of PDF downloads 961 | Article publication date 01/08/2004

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ABSTRACT

INTRODUCTION In some studies in children, topiramate showed efficacy. OBJECTIVE. To evaluate efficacy, tolerability and safety of topiramate in monotherapy in newly diagnosed epilepsy vs carbamazepine in children.

PATIENTS AND METHODS In a multicentre, open-label, comparative and randomized study patients with partial epilepsy, were randomized to received topiramate or carbamazepine treatment. Patients with degenerative disease were excluded. Data were analysed by SPSS statistical program v. 11.0, and non parametric test. Comparisons between groups were made with chi square test and t Student’s test.

RESULTS In total were included 88 patients, 33 in group 1 (topiramate), 32 group 2 (carbamazepine), 23 were drop-outs because adverse events and lost in follow-up (13 in group 1 y 10 group 2). In both groups were observed good efficacy, in month 6 and 9 of follow-up, the average of seizures in group 1 were better than group 2 (p = 0.01, t Student’s test). The percentage of free seizure patients was greater in group 1 than group 2 (statistical significance p = 0.02 chi square test). The adverse events were similar in both groups and mild, somnolence 9%, weight loss 6% in group 1 and somnolence 19%, dizziness 3% and seizure discontrol 3% in group 2.

CONCLUSIONS Good efficacy in both groups, and topiramate in good treatment choice in newly diagnosed epilepsy in children because it’s the efficacy and tolerability in comparison with the gold standard carbamazepine. KeywordsAntiepileptic drugs Monotherapy Newly diagnosed epilepsy Seizures Topiramate CategoriesEpilepsias y síndromes epilépticos Neuropediatría

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Original

A randomised open trial comparing monotherapy with topiramate versus carbamazepine in the treatment of paediatric patients with recently diagnosed epilepsy

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