Preadmission statins treatment in stroke patients: opportunity to treat high vascular risk patients

J. Carneado-Ruiz, J. Sánchez-Payá, A. Alfaro-Sáez, M. Lezcano-Rodas, L. Berenguer-Ruiz, F. Mira-Berenguer, N. López-Hernández, A. García-Escrivá, J.M. Moltó-Jordà, F. Gracia-Fleta [REV NEUROL 2007;45:449-455] PMID: 17948209 DOI: https://doi.org/10.33588/rn.4508.2007455 OPEN ACCESS
Volumen 45 | Number 08 | Nº of views of the article 4.620 | Nº of PDF downloads 614 | Article publication date 16/10/2007
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ABSTRACT Artículo en español English version
AIM To describe the use of preadmission statins in patients with cerebrovascular accident and the possible predictive factors.

PATIENTS AND METHODS Cross-sectional observational study of 795 consecutive patients with acute cerebrovascular accident. We assessed the differences among patients who were on preadmission statins (161) and those who were not (634), regarding vascular risk factors and clinical and neurosonological atherothrombotic disease markers. For univariate analysis, we used squared chi test, and for multivariate analysis, logistic regression analysis.

RESULTS Preadmission statins were 20.3%. In high vascular risk patients defined based on National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III), this reached 28% and it might be 72%. Predictive factors for preadmission statins use were, in a positive sense, the antecedent of hypercholesterolemia diagnosis (OR = 189; 95% CI = 58-615; p £ 0.001) and stroke (OR = 2.1; 95% CI = 1.2-3.6; p £ 0.01), and in a negative sense, smoking (OR = 0.38; 95% CI = 0.18-0.81; p = 0.012).

CONCLUSIONS In our population of patients with stroke, the predictive factors of preadmission statins did not adjust to the current therapeutic NCEP-ATP III recommendations; treatment with statins in high vascular risk population was way below the indications, it was 28% and it might be 72%.
KeywordsGuidelinesHypercholesterolemiaPredictorStatinsStrokeStroke-unitTIA CategoriesPatología vascular
FULL TEXT Artículo en español English version