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PANDAS with a chorea-like clinical presentation and associated autoimmune pathology: a case report

S. Otero-Cuesta, O. Fernández-Torre, D. González-Lamuño [REV NEUROL 2009;49:76-78] PMID: 19598136 DOI: https://doi.org/10.33588/rn.4902.2008355

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Volumen 49 | Number 02 | Nº of views of the article 5.267 | Nº of PDF downloads 896 | Article publication date 16/07/2009

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ABSTRACT

INTRODUCTION The disorder known as ‘PANDAS syndrome’ (paediatric autoimmune neuro-psychiatric disorders associated with Streptococci) consists in an abrupt onset of obsessive-compulsive symptoms and/or movement disorders, a pre-puberal onset, and an episodic course. Antibiotic therapy has been postulated as a first choice therapeutic option. A summarised review of main literature on this topic is presented.

CASE REPORT A girl, 10 years and 6 months old, with a dramatic clinical onset of a chorea-like and obsessive-compulsive symptomathology with a remarkable improvement after 10 days penicillin p.o. intake. She has a positive family history of autoimmune disorders, with elevated anti-phospholipidic antibodies. CONCLUSION. The implications of the case follow-up with many relapses, the development of a diabetes after corticoid therapy and the elevated anti glutamic dexcarboxilasa (anti-GAD) are discussed regarding a common underlying autoimmune mechanism. KeywordsAntiphospholipid syndrome Autoimmune disorder Chorea Compulsive disorder Obsessive disorder PANDAS Tic disorder

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Nota Clínica

PANDAS with a chorea-like clinical presentation and associated autoimmune pathology: a case report

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