Guía

Consensus clinical practice guidelines of the Andalusian Epilepsy Society on prescribing generic antiepileptic drugs

F.M. Cañadillas-Hidalgo, J.C. Sánchez-Álvarez, P. Serrano-Castro, J.M. Mercadé-Cerdá, en representación de la Sociedad Andaluza de Epilepsia [REV NEUROL 2009;49:41-47] PMID: 19557699 DOI: https://doi.org/10.33588/rn.4901.2009043

OPEN ACCESS

Volumen 49 | Number 01 | Nº of views of the article 5.017 | Nº of PDF downloads 1.297 | Article publication date 01/07/2009

Download PDF Castellano Citation Search in PubMed

Share in:

Go to another issue

ABSTRACT

INTRODUCTION Pharmaceutical spending in Spain accounts for 1.2-1.4% of the gross domestic product and is increasing by 5-12% per year. One of the measures adopted by the government to cut this spending is the possible substitution of original prescribed drugs by generics. In the case of antiepileptic drugs (AED), which are characterised by a scant therapeutic margin, these steps have sparked a scientific debate about their repercussion on the control of epileptic patients. We propose to draw up a set of implicit evidence-based consensus practice guidelines concerning issues related with this topic. DEVELOPMENT. A selective search for quality scientific information on the subject was conducted on PubMed-Medline, Tripdatabase and the Biblioteca Cochrane Plus. The selected references were analysed and discussed by the authors, and the recommendations deriving from them were collected. A total of 21 primary documents and 16 practice guidelines, protocols or experts’ recommendations were identified. Our recommendations were explicitly included at the end of the text.

CONCLUSIONS The Andalusian Epilepsy Society makes the following recommendations: 1) not replacing an innovative AED by its generic in a controlled patient; 2) beginning treatment with a generic AED in monotherapy or in association is acceptable; 3) not exchanging generic AED from different pharmaceutical companies; 4) explaining to the patient the rules governing the authorisation of generics and the importance of avoiding exchanges between different generic AED; and 5) if there is some worsening of the clinical condition or side effects appear following the introduction of a generic, the causes must be investigated and communicated to the bodies responsible for pharmacovigilance. KeywordsActive ingredient Antiepileptic drugs Clinical practice guidelines Consensus Epilepsy Evidence-based medicine Generic drugs Health care protocol Pharmacokinetics Treatment

FULL TEXT (solo disponible en lengua castellana / Only available in Spanish)

Acceso directo al último número

Último Podcast

Guía

Consensus clinical practice guidelines of the Andalusian Epilepsy Society on prescribing generic antiepileptic drugs

¡CONVIÉRTASE EN USUARIO PREMIUM DE NEUROLOGIA.COM!

Al hacerse premium, está apoyándonos para que Revista de Neurología siga siendo uno de los referentes de habla hispana en la difusión del conocimiento en neurociencias. ¡Gratuita tanto para autores como para todos los usuarios de la web!