Original

Homocysteine and cognitive impairment in Parkinson’s disease

J.J. Martín-Fernández, R. Carles-Díes, F. Cañizares, S. Parra, F. Avilés, I. Villegas, O. Morsi-Hassan, A. Fernández-Barreiro, M.T. Herrero [REV NEUROL 2010;50:145-151] PMID: 20146187 DOI: https://doi.org/10.33588/rn.5003.2009276

OPEN ACCESS

Volumen 50 | Number 03 | Nº of views of the article 8.144 | Nº of PDF downloads 913 | Article publication date 01/02/2010

Download PDF Castellano Citation Search in PubMed

Share in:

Go to another issue

ABSTRACT

INTRODUCTION The relationship between homocysteine (Hc) and vascular diseases has been known for more than 30 years. Lately, Hc has also been related to cognitive and motor impairment. In Parkinson’s disease (PD), chronic treatment with levodopa could induce higher levels of Hc, and thus may increase risk of cognitive impairment. AIMS. To confirm that PD patients treated with levodopa have higher levels of Hc and to establish a relationship between Hc, folic acid and vitamin B12 levels. Also, we studied a possible link between those variables and cognitive function.

PATIENTS AND METHODS 58 patients with diagnosis of PD were included (45 under treatment with levodopa). Basal levels of Hc, vitamin B12 and folic acid were determined. Forty five patients underwent neuropsychological evaluation.

RESULTS Hc levels were significantly higher in patients taking levodopa and were not related to levodopa dosage or treatment duration. There was a negative correlation between Hc levels and those of vitamin B12 and folic acid in men but we found no such correlation in women. Entacapone was not found to reduce Hc levels. Hc levels were significantly higher in patients with cognitive impairment (9 out of 45 patients).

CONCLUSIONS Our study confirms presence of high levels of Hc in PD patients under treatment with levodopa, more evident in patients with cognitive impairment. KeywordsCognitive impairment Folic acid Homocysteine Levodopa Parkinson Vitamin B12 CategoriesNeurodegeneración Neuropsicología Trastornos del movimiento

FULL TEXT (solo disponible en lengua castellana / Only available in Spanish)

Acceso directo al último número

Último Podcast

Original

Homocysteine and cognitive impairment in Parkinson’s disease

¡CONVIÉRTASE EN USUARIO PREMIUM DE NEUROLOGIA.COM!

Al hacerse premium, está apoyándonos para que Revista de Neurología siga siendo uno de los referentes de habla hispana en la difusión del conocimiento en neurociencias. ¡Gratuita tanto para autores como para todos los usuarios de la web!