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Psychological and behavioural symptoms as factors of progression to Alzheimer-type dementia in mild cognitive impairment

J.C. Reyes-Figueroa, M. Rosich-Estragó, E. Bordas-Buera, A.M. Gaviria-Gómez, E. Vilella, A. Labad-Alquézar [REV NEUROL 2010;50:653-660] PMID: 20514637 DOI: https://doi.org/10.33588/rn.5011.2009714

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Volumen 50 | Number 11 | Nº of views of the article 10.295 | Nº of PDF downloads 3.391 | Article publication date 01/06/2010

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ABSTRACT

INTRODUCTION Mild cognitive impairment (MCI) is a cognitive disturbance in which intensity is not enough to be classified as dementia and does not affect significantly the functioning or activities of daily living. The MCI has a progression rate to Alzheimer-type dementia (ATD) related to different factors.

AIM To evaluate the association between the presence of psychological and behavioural symptoms (PBS) with progression to ATD en MCI subjects.

PATIENTS AND METHODS We evaluated 318 patients with MCI assessed in a Dementia Unit of Catalonia between 1998 to 2002 who were followed five years after the MCI diagnosis. We determined the PBS presence, those classified as affective, behavioural and psychotic symptoms. We also assessed sociodemographic aspects and the ApoE genotype.

RESULTS The mean age was 74 ± 7.87 years-old, 56.7% presented PBS, with affective (53%), behavioural (32.2%) and psychotic symptoms (14.8%). In the study, 32.1% progressed to ATD. We found association between the presence of PBS and the progression to ATD (OR = 2.77; 95% CI = 1.66-4.63), specifically with behavioural and psychotic symptoms. The ApoE epsilon4 allele showed association with the progression to ATD (OR = 1.81; 95% CI = 1.11-2.94). The logistic regression model showed a significant association between the PBS and the epsilon4 allele with the progression to ATD.

CONCLUSIONS The PBS presence in MCI patients is associated with ATD progression with or without ApoE epsilon4 allele. KeywordsAlzheimer type dementia Apolipoprotein E Disease progression Genetics Mild cognitive impairment Psychological and behavioral symptoms CategoriesDemencia Neurodegeneración Neuropsicología Neuropsiquiatría

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Psychological and behavioural symptoms as factors of progression to Alzheimer-type dementia in mild cognitive impairment

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