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Relationship between fibrinolytic system and neurological diseases

M.A. Zea-Sevilla, P. Bermejo, F. Carrillo [REV NEUROL 2010;51:295-301] PMID: 20669129 DOI: https://doi.org/10.33588/rn.5105.2010047

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Volumen 51 | Number 05 | Nº of views of the article 12.793 | Nº of PDF downloads 862 | Article publication date 01/09/2010

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ABSTRACT

INTRODUCTION The fibrinolytic system, also named plasminogen system is formed by a group of molecules that transforms plasminogen in its active form plasmine, which is able to participate in a number of pathophysiological processes.

AIM To carry out a review of the literature and an analysis of the relationship between fibrinolytic system and neurological diseases and its potential therapeutic implications. DEVELOPMENT. The fibrinolytic system has been involved in many different pathologies. Although its role in neurological diseases has always been thought to be scarce, many relations have been recently established. This way, fibrinolytic system seems to be involved not only in cerebrovascular diseases but also in epilepsy, inflammatory diseases such as multiple sclerosis, alterations of the dopaminergic system, learning disorders and several lesions of the peripheral nervous system. Different genotypes of several components of this system have been related as risk or protector factors to the development of these neurological diseases and information to this respect is rapidly increasing.

CONCLUSIONS A better knowledge about the relations between the fibrinolytic system and neurological diseases could clarify several aspects about their pathophysiology and it could suppose future prevention and treatment lines. KeywordsBlood coagulation Epilepsy Fibrinogen Multiple sclerosis Plasminogen Plasminogen activator inhibitor Stroke Tissue plasminogen activator CategoriesEpilepsias y síndromes epilépticos Esclerosis múltiple Patología vascular

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