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Voltage sources in mesial temporal area induced by etomidate

I. Herrera-Peco, G.J. Ortega, V. Hernando-Requejo, R. García-Sola, J. Pastor [REV NEUROL 2010;51:263-270] PMID: 20669125 DOI: https://doi.org/10.33588/rn.5105.2010193

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Volumen 51 | Number 05 | Nº of views of the article 5.377 | Nº of PDF downloads 431 | Article publication date 01/09/2010

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ABSTRACT

INTRODUCTION It has been recently shown that activation of the EEG by etomidate is a specific and safe technique during the evaluation of patients for epilepsy surgery.

AIM To analyze the pathophysiological properties of interictal activity induced by etomidate and compare with the interictal spontaneous activity.

PATIENTS AND METHODS We studied 13 patients by video-EEG with foramen ovale electrodes. Etomidate (0.1 mg/kg) was injected to activate the epileptogenic region. The activity of foramen ovale electrodes was adjusted to a monopolar voltage source.

RESULTS Interictal activity mediated by etomidate fits well to a monopolar model, in the same way that the basal interictal activity. The voltage sources distribution recorded during the interictal activity and distribution of voltage sources recorded in presence of etomidate have similar topographical properties. The equivalent charge induced by etomidate was higher than the basal one.

CONCLUSIONS The basal and etomidate induced activity have similar electrophysiological properties, suggesting that the same or similar structures are responsible of both. So, etomidate can be used as an specific inductor of EEG activity during presurgical evaluation. KeywordsEtomidate Interictal activity Monopolar model Temporal lobe epilepsy voltage sources CategoriesEpilepsias y síndromes epilépticos

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Voltage sources in mesial temporal area induced by etomidate

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