Ponencia

Therapeutic plasmapheresis and experience in Alzheimer’s disease

F. Anaya [REV NEUROL 2010;50 (Supl. 5):S5-S8] PMID: 20517867 DOI: https://doi.org/10.33588/rn.50S05.2010269

OPEN ACCESS

Volumen 50 | Number S05 | Nº of views of the article 10.329 | Nº of PDF downloads 887 | Article publication date 16/03/2010

Download PDF Castellano Citation Search in PubMed

Share in:

Go to another issue

ABSTRACT

BACKGROUND AND STUDY DEVELOPMENT. Therapeutic apheresis is a treatment strategy aimed at removing and eliminating from blood those substances that are considered pathogenically responsible for a disease or its clinical manifestations. In a therapeutic plasmapheresis (plasma exchange), a volume of circulating plasma is extracted and usually substituted by a 5% albumin solution or, exceptionally, by fresh plasma. Beta-amyloid peptide (Aß) is the main proteinaceous component of the extracellular senile plaque found in the brain parenchyma involved in memory function. Both extracellular senile plaque and neurofibrillar tangles are characteristic of Alzheimer’s disease (AD). Considering that 90% of circulanting Aß is linked to albumin, a mobilization of plasma Aß after plasmapheresis could induce a mobilization of brain Aß and, as a consequence, the decline of cognitive functions in AD patients could be prevented. With this objective, a clinical program was developed to investigate the feasibility of plasmapheresis with Human Albumin Grifols ® 5% in patients with AD.

CONCLUSIONS Plasmapheresis is feasible in this complex patient population in terms of treatment, safety and tolerability. Moreover, a trend towards plasma Aß mobilization associated with an improvement in neuropsychological evaluation was observed. KeywordsAlbumin Alzheimer’s disease Plasma exchange Plasmapheresis Therapeutic apheresis CategoriesDemencia Neurodegeneración

FULL TEXT (solo disponible en lengua castellana / Only available in Spanish)

Acceso directo al último número

Último Podcast

Ponencia

Therapeutic plasmapheresis and experience in Alzheimer’s disease

¡CONVIÉRTASE EN USUARIO PREMIUM DE NEUROLOGIA.COM!

Al hacerse premium, está apoyándonos para que Revista de Neurología siga siendo uno de los referentes de habla hispana en la difusión del conocimiento en neurociencias. ¡Gratuita tanto para autores como para todos los usuarios de la web!