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Resveratrol: a neuroprotective polyphenol in the Mediterranean diet

V. López-Miranda, M.L. Soto-Montenegro, G. Vera, E. Herradón, M. Desco, R. Abalo [REV NEUROL 2012;54:349-356] PMID: 22403148 DOI: https://doi.org/10.33588/rn.5406.2011611

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Volumen 54 | Number 06 | Nº of views of the article 9.668 | Nº of PDF downloads 1.185 | Article publication date 16/03/2012

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ABSTRACT

INTRODUCTION Resveratrol is a polyphenol present in grapes, some nuts and dried fruits, and red wine. A number of beneficial properties have been attributed to this compound. Its potential neuroprotective effects are the subject of much research today.

AIM To review the effects of resveratrol, and more particularly those related to its capacity to offer protection against the neurodegeneration associated with several pathologies and traumatic injuries in the central nervous system. DEVELOPMENT. It has been suggested that the daily consumption of red wine, and therefore of resveratrol, could account for the so-called ‘French paradox’, according to which the population in the south of France, despite eating a diet that is relatively high in saturated fats, presents a low risk of heart disease. From this first evidence of the cardioprotective properties of resveratrol, its study has been extended and equally attractive biopharmacological effects have now been found in many different fields. Thus, neuroprotective effects have been found in models of neurodegeneration (Alzheimer’s, Parkinson’s or Huntington’s disease, or diverse neuropathies), of ischaemia and of brain and spinal cord injury, but further clinical data are still needed in this regard.

CONCLUSIONS Although few studies have been conducted in humans, recent findings in experimental models of neurological pathology are encouraging and open up the doors to future clinical studies that will allow the therapeutic value of resveratrol to be determined. KeywordsBrain damage Neurodegenerative diseases Neuropathy Neuroprotection Resveratrol Sirtuins Spinal cord injury CategoriesNervios periféricos, unión neuromuscular y músculo

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Resveratrol: a neuroprotective polyphenol in the Mediterranean diet