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Pharmacogenetics and antiepileptic drug metabolism: implication of genetic variants in cytochromes P450

A.M. Saldaña-Cruz, J. Sánchez-Corona, D.A. Márquez de Santiago, A.G. García-Zapién, S.E. Flores-Martínez [REV NEUROL 2013;56:471-479] PMID: 23629749 DOI: https://doi.org/10.33588/rn.5609.2013131

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Volumen 56 | Number 09 | Nº of views of the article 8.351 | Nº of PDF downloads 1.083 | Article publication date 01/05/2013

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ABSTRACT

INTRODUCTION Antiepileptic drugs (AEDs) are used for the seizures control in patients with epilepsy, however 20-30% of epileptic patients are drug resistant. Several factors contributing to the variability of the AEDs response, and this variability can be partially attributed to the presence of sequence variations (polymorphisms) in genes encoding enzymes involved in the AEDs metabolism.

AIM To describe the polymorphisms in genes that encoding for proteins involved in the metabolism of some of the major AEDs, focusing on enzymes cytochrome P450 (CYP450). DEVELOPMENT. There are some polymorphisms in genes encoding proteins involved in drug metabolism, particularly enzymes of superfamily CYP450, that are already considered of clinical utility in the therapeutic management. These genetic variants contribute to the variability of the activity of metabolizing enzymes, which in turn influencing the poor or inadequate therapeutic response, as well as in the occurrence of adverse effects.

CONCLUSIONS The identification of interindividual variability in the response to AEDs may allow the personalized treatment with the aim of maximize the efficiency and minimize risk, regardless of the clinical variability and adverse effects could be manifest in a minority of the patients. KeywordsAntiepileptic drugs CYP450 enzymes Drug resistance Epilepsy Genetic variants Pharmacogenetics CategoriesEpilepsias y síndromes epilépticos

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Pharmacogenetics and antiepileptic drug metabolism: implication of genetic variants in cytochromes P450

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