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Functional connectivity and complex networks in focal epilepsy. Pathophysiology and therapeutic implications

J. Pastor, R. García-Sola, L. Vega-Zelaya, O. Garnés, G.J. Ortega [REV NEUROL 2014;58:411-419] PMID: 24777769 DOI: https://doi.org/10.33588/rn.5809.2013581

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Volumen 58 | Number 09 | Nº of views of the article 5.157 | Nº of PDF downloads 1.067 | Article publication date 01/05/2014

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ABSTRACT

INTRODUCTION The traditional surgical approach to treat drug-resistant focal epileptic patients is in the resection or disconnection of the epileptic focus. However, a significant minority of patients continue to experience seizures after surgery, which shows the incomplete level of knowledge that currently we have of this pathology.

AIM This paper introduces some concepts of functional connectivity and complex networks methodology with its application to the study of neurophysiological recordings from patients suffering from drug-resistant focal epilepsy. DEVELOPMENT. In order to fully understand the new developments in the area of complex networks and its applications to the study of epilepsy, we will here review fundamental concepts in complex networks methodology, synchronization and functional connectivity. Some of the most recent published works dealing with focal epilepsy viewed under this new perspective will be revised and commented.

CONCLUSIONS We think that a wider perspective in the study of epilepsy, such as the one reviewed in this work, will allow epileptologists to consider surgical alternatives in the usual treatment of focal epilepsy at those currently performed in most medical centers around the world. Combining the traditional knowledge with new insights provided by network theory will certainly fill many of the gaps we have today in the fragmented understanding of epilepsy. KeywordsComplex network Electroencephalography Functional connectivity Synchronization Temporal lobe epilepsy CategoriesEpilepsias y síndromes epilépticos Técnicas exploratorias

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Functional connectivity and complex networks in focal epilepsy. Pathophysiology and therapeutic implications

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