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Effect of partial and generalised epileptic seizures on sleep architecture in rats

E. López-Ruiz, G. Vega-Flores, B. Contreras-Cisneros, A. Martínez, A.P. Rivera-García [REV NEUROL 2015;60:289-295] PMID: 25806477 DOI: https://doi.org/10.33588/rn.6007.2014318

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Volumen 60 | Number 07 | Nº of views of the article 6.261 | Nº of PDF downloads 344 | Article publication date 01/04/2015

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ABSTRACT

INTRODUCTION It is a well-known fact that epileptic seizures disrupt sleep, yet little information is available about sleep disorders according to the type of epileptic seizures.

MATERIALS AND METHODS The sleep architecture of rats was evaluated in polysomnography recordings 36 hours after inducing partial and generalised epileptic seizures in them. The epileptic seizures were induced by applying 50-100 IU of sodium G penicillin in the amygdala of the temporal lobe.

RESULTS Partial and generalised seizures triggered an increase in the latency of slow wave sleep (SWS) and rapid eye movement (REM) sleep. The number of episodes of the phases of wakefulness, SWS and REM sleep was reduced and the mean duration of the episodes of wakefulness and SWS increased, while that of REM sleep diminished. The total percentage of REM sleep diminished significantly. During the first period of light the partial and generalised seizures triggered an increase in wakefulness and a reduction in the phases of SWS and REM sleep. In the period of darkness, the SWS increased and wakefulness decreased, while there were no changes in REM sleep. In the second period of light, the percentages of the phases of wakefulness and SWS returned to control values and the percentage of REM sleep continued to be reduced.

CONCLUSIONS Changes in the structuring of sleep depend on the type of epileptic seizure that presents. Generalised epileptic seizures caused greater deterioration in REM sleep. KeywordsBehavioural stages of epilepsy in rats Generalised seizures Partial seizures Sleep architecture Temporal lobe amygdala Temporal lobe epilepsy CategoriesEpilepsias y síndromes epilépticos Neuropsiquiatría Sueño

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Original

Effect of partial and generalised epileptic seizures on sleep architecture in rats