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Arterial pathology in migraine: endothelial dysfunction and structural changes in the brain and systemic vasculature

D. Larrosa-Campo, C. Ramón-Carbajo, R. Álvarez-Escudero, E. Cernuda-Morollón, C. García-Cabo, J. Pascual [REV NEUROL 2015;61:313-322] PMID: 26411276 DOI: https://doi.org/10.33588/rn.6107.2015226

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Volumen 61 | Number 07 | Nº of views of the article 8.185 | Nº of PDF downloads 785 | Article publication date 01/10/2015

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ABSTRACT

INTRODUCTION The pathophysiology underlying the association between migraine and other non-atherosclerotic vascular diseases is largely unknown. Endothelial dysfunction has been proposed as a common link. Besides, endothelial dysfunction is considered as a predictor of structural changes in the arterial walls.

AIM To review the current knowledge about the functional (endothelial dysfunction) and structural (arterial stiffness and atherosclerotic diseases) arterial properties associated with migraine. DEVELOPMENT. Studies of biological markers of endothelial dysfunction in peripheral blood, systemic and cerebral vasoreactivity, arterial stiffness indexes and direct visualization of macroscopic changes in the arterial wall have shown differences between patients with and without migraine, as well as between the different migraine subtypes.

CONCLUSIONS Endothelial dysfunction, as a predictor of structural changes in arteries, has been proposed as an early marker for vascular pathology associated with migraine. In migraine patients there is an increase of biomarkers of endothelial dysfunction, but the correlation with vasoreactivity studies does not allow definite conclusions. Available data do not allow to conclude that migraine is associated with macroscopic alterations outside the cerebral arterial bed. KeywordsArterial stiffness Atherosclerosis Biomarkers Endothelial dysfunction Migraine Vasoreactivity CategoriesCefalea y Migraña Dolor

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Arterial pathology in migraine: endothelial dysfunction and structural changes in the brain and systemic vasculature

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