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Clinical experience with lacosamide in Galicia: the GALACO study

X. Rodríguez-Osorio, F.J. López-González, A. Pato-Pato, E. Cebrián-Pérez, J. Marey-López, E. Corredera-García, E. Rubio-Nazábal, M.D. Castro-Vilanova, J. Abella-Corral, A. Rodríguez-Regal, M.C. Amigo-Jorrín, R. Pego-Reigosa, e.r. [REV NEUROL 2015;61:536-542] PMID: 26662871 DOI: https://doi.org/10.33588/rn.6112.2015359

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Volumen 61 | Number 12 | Nº of views of the article 5.446 | Nº of PDF downloads 315 | Article publication date 16/12/2015

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ABSTRACT

INTRODUCTION Lacosamide is a sodium channel blocker antiepileptic drug authorized as an adjunctive therapy for focal seizures in adolescents and adults.

AIM To analyze the efficacy and safety of lacosamide in Galicia according to its use in daily clinical practice.

PATIENTS AND METHODS Retrospective observational study in patients who started treatment with lacosamide between January 2014 and June 2013 in 10 hospitals in Galicia, Spain. Its efficacy and safety at 3, 6 and 12 months after starting lacosamide was assessed.

RESULTS We included 184 patients with a mean age of 44.2 ± 17.4 years old; 56.5% (n = 104) were male; 173 patients constituted the efficacy population. Mean duration of epilepsy was 18.8 ± 15.5 years. Seizure frequency was 2.5 ± 1.6 episodes/month. After 12 months, 68.2% of patients (n = 118) had >= 50% improvement (responders) and among them, 54 (45.8% of responder patients) were seizure free. Twenty-three percent (n = 43) suffered from adverse events after 12 months, being dizziness (10.3%) and instability (3.3%) the most frequently reported. After the 12 month visit, 87.5% of patients (n = 161) continued treatment with lacosamide.

CONCLUSIONS Lacosamide provides a very good efficacy and safety profile for patients with focal refractory epilepsy. High percentage of responders may be related to a less refractory population compared to other daily clinical practice studies. It constitutes an attractive therapeutic option for the treatment of focal epilepsies. KeywordsAEDs Focal epilepsy Lacosamide Observational study Refractory epilepsy Seizures CategoriesEpilepsias y síndromes epilépticos

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Clinical experience with lacosamide in Galicia: the GALACO study

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