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Optic neuritis in childhood. A pediatric series, literature review and treatment approach

D. López-Martín, J.L. Martínez-Antón [REV NEUROL 2016;63:103-108] PMID: 27412016 DOI: https://doi.org/10.33588/rn.6303.2015407

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Volumen 63 | Number 03 | Nº of views of the article 12.756 | Nº of PDF downloads 878 | Article publication date 01/08/2016

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ABSTRACT

INTRODUCTION In children, the most common form of optic neuritis usually occurs after an infectious disease with papilledema, usually bilateral and has a good prognosis. Conversion to multiple sclerosis is low.

AIM To present clinical and laboratory case of optic neuritis in pediatrics features.

PATIENTS AND METHODS Seventeen clinical cases of optic neuritis in children and young people aged 4-14 years, referred from 2000 to 2015 were analyzed.

RESULTS The median age of the series was 11 years. They predominated the female patients and infectious history was uncommon; in five of 17 patients was bilateral engagement and four cases evolved with retrobulbar optic neuritis. Magnetic resonance imaging showed hyperintensity on T2 in the optic nerves affected in five patients. The study of cerebrospinal fluid and oligoclonal bands was normal in all cases. Patients treated with intravenous methylprednisolone had good recovery. It was found subsequent evolution to multiple sclerosis only in three cases.

CONCLUSIONS In our series, the cases that evolved multiple sclerosis showed no clinical differences although they had a higher number of hyperintense lesions on magnetic resonance imaging. This fact, described in previous studies, supports our diagnostic and therapeutic scheme in an attempt to approach the optimal management of this disease. KeywordsChildhood Corticosteroids Magnetic resonance imaging Multiple sclerosis Optic neuritis Visual prognosis CategoriesEsclerosis múltiple Neuropediatría

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Original

Optic neuritis in childhood. A pediatric series, literature review and treatment approach

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