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Month of birth, HLA-DRB1*15 locus and risk of multiple sclerosis in offspring

C. Guijarro-Castro, E. Sánchez-Zapardiel, D. Muñoz, Ó. Fernández, L. Leyva, M.J. Castro-Panete, C. Picón-Muñoz, M. Talise, A. Martínez-Feito, E. Paz-Artal [REV NEUROL 2016;63:201-205] PMID: 27569565 DOI: https://doi.org/10.33588/rn.6305.2016114

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Volumen 63 | Number 05 | Nº of views of the article 10.290 | Nº of PDF downloads 452 | Article publication date 01/09/2016

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ABSTRACT

INTRODUCTION A relationship among April births, HLA-DRB1*15:01 genotype and risk of multiple sclerosis (MS) has been described. We aim to determine this association in our cohort of Spanish MS patients.

SUBJECTS AND METHODS We genotyped HLA-DRB1*15:01 allele in 326 MS patients and 226 controls (non-neurological disease patients) by SSP-PCR and compared month of birth with local births during the same period.

RESULTS MS patients carrying HLA-DRB1*15 allele were more frequently born in December (10.3% HLA-DRB1*15+ vs. 3.8% HLA-DRB1*15–; p = 0.019). Controls carrying HLA-DRB1*15 allele were less frequently born in December than non-carrier controls (0% HLA-DRB1*15+ vs. 10.3% HLA-DRB1*15–; p = 0.028). Thus, December was confirmed as the common month of birth for HLA-DRB1*15-non-carrier controls and MS HLA-DRB1*15-carrier patients.

CONCLUSIONS Month of birth, HLA-DRB1 genotype and risk of MS are associated. In Spain, this association was found in December, supporting the potential interaction of a seasonal risk factor in winter, inside/close to HLA-DRB1*15 locus, during pregnancy or after birth. KeywordsDecember HLA-DRB1*15 Month of birth Multiple sclerosis Spain CategoriesEsclerosis múltiple

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Month of birth, HLA-DRB1*15 locus and risk of multiple sclerosis in offspring

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