Original

Long-term effect of policosanol on the functional recovery of non-cardioembolic ischemic stroke patients: a one year study

J. Sánchez-López, J. Illnait-Ferrer, R. Mas-Ferreiro, S. Mendoza-Castaño, L. Fernández-Dorta, M. Mesa-Angarica, H. Vega, J. Fernández, P. Reyes-Suárez, D. Ruiz [REV NEUROL 2017;64:153-161] PMID: 28169410 DOI: https://doi.org/10.33588/rn.6404.2016180

OPEN ACCESS

Volumen 64 | Number 04 | Nº of views of the article 6.809 | Nº of PDF downloads 207 | Article publication date 16/02/2017

Download PDF Castellano Citation Search in PubMed

Share in:

Go to another issue

ABSTRACT

INTRODUCTION Stroke is a leading cause of mortality and disability. Policosanol has been effective in brain ischemia models. The aim of this study is to investigate whether policosanol, added to aspirin therapy within 30 days of stroke onset, is better than placebo + aspirine for the long-term recovery of non-cardioembolic ischemic stroke subjects.

PATIENTS AND METHODS Randomized, double-blind, placebo-controlled study. Eighty patients (mean age: 69 years) within 30 days of onset, with a modified Rankin Scale score (mRS) 2 to 4, were included. They were randomized in two groups (policosanol + aspirine or placebo + aspirine) for 12 months.

RESULTS Policosanol + aspirine decreased significantly mean mRS from the first interim check-up (1.5 months). The treatment even improved after long-term therapy. More policosanol + aspirin (87.5%) than placebo + aspirine (0%) patients achieved mRSs <= 1. Policosanol + aspirine increased significantly Barthel Index, lowered LDL-cholesterol and increased HDL-cholesterol versus placebo + aspirin.

CONCLUSIONS Long-term (12 months) administration of policosanol + aspirin given after suffering non-cardioembolic ischemic stroke was shown to be better than placebo + aspirin in improving functional outcomes when used among patients with non-cardioembolic ischemic stroke of moderate severity. KeywordsAspirin Barthel index Modified Rankin Scale Non-cardioembolic ischemic stroke Placebo Policosanol CategoriesPatología vascular

FULL TEXT (solo disponible en lengua castellana / Only available in Spanish)

Acceso directo al último número

Último Podcast

Original

Long-term effect of policosanol on the functional recovery of non-cardioembolic ischemic stroke patients: a one year study

¡CONVIÉRTASE EN USUARIO PREMIUM DE NEUROLOGIA.COM!

Al hacerse premium, está apoyándonos para que Revista de Neurología siga siendo uno de los referentes de habla hispana en la difusión del conocimiento en neurociencias. ¡Gratuita tanto para autores como para todos los usuarios de la web!