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Neurological effects of hypoglycemia in diabetic patients

J. Caballero-Corchuelo [REV NEUROL 2016;63:262-268] PMID: 27600741 DOI: https://doi.org/10.33588/rn.6306.2016198

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Volumen 63 | Number 06 | Nº of views of the article 22.609 | Nº of PDF downloads 1.096 | Article publication date 16/09/2016

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ABSTRACT

INTRODUCTION The pharmacological treatment of diabetes is associated with an increased risk of hypoglycemia. Hypoglycemic events affect the quality of life of patients and can lead to long-term neurological consequences.

AIM To review the neurological effects of hypoglycemia in diabetic patients. DEVELOPMENT. After reviewing the pathophysiology of hypoglycemia in diabetic patients we will review the role of hypoglycemia in three clinical situations: the hypoglycemia-associated autonomic failure, the brain effects of hypoglycemia in children and the relationship of hypoglycemia and cognitive decline in older patients.

CONCLUSIONS Apart from acute and severe neurological damages that can occur in cases of prolonged hypoglycemia, repeated episodes of hypoglycemia are associated with other deleterious neurological effects. Frequent episodes can weaken the counter-regulatory responses to subsequent episodes of hypoglycemia, increasing the risk of severe hypoglycemia and can lead to long-term consequences in cognitive functions in vulnerable populations such as the elderly or young children. KeywordsAutonomic Awareness Childhood Dementia Diabetes Hypoglycemia CategoriesDemencia Neuropsiquiatría

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Neurological effects of hypoglycemia in diabetic patients

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