T-cell interferon-g, tumor necrosis factor-a and interleukin-6 receptor binding in patients with multiple sclerosis. Effects of interferon-b 1b treatment
INTRODUCTION Multiple sclerosis (MS) is a Tcellmediated demyelinating disease of the central nervous system (CNS), in which the cytokine network may be deranged. Interferon (IFN)g, interleukin (IL)6, and tumor necrosis factor (TNF)a are cytokines with several effects on the neuroimmune system. Specific IFNg, IL6, and TNFa receptors have been found on human lymphocytes and other cell types.
PATIENTS AND METHODS We assayed IFNg, TNFa, and IL6 binding on peripheral blood T cells from MS patients, as compared with healthy subjects. T cells from MS patients have significantly less IFNg receptors, and more TNFa and IL6 receptors than those from controls. Such receptors are of the same type in patients and healthy subjects. By comparing MS patients’ subgroups with each other, significant differences in mean Bmax values have been found between patients in a stable phase and those in relapse, and between stable patients and those in an evolutive phase. As far as IL6 binding is concerned, significant differences in mean Bmax values were observed only between patients in stable phase and those in relapse.
RESULTS T lymphocytes from untreated MS patients, which had significantly smaller amounts of IFNg receptors than those from controls, and more TNFa and IL6 receptors than controls showed a significant increase in IFNg binding, and a significant decrease in TNFa and IL6 binding after a 3month IFNb1b treatment. Tcell IFNg Bmax values were even higher, and those of TNFa and IL6 were lower after 6 months. CONCLUSION. We discuss these results in terms of MS immunopathophysiology, since activated T cells have decreased IFNg, and increased TNFa and IL6 receptor amounts
KeywordsCytokinesInterferonbInterferongInterleukin6LymphocytesMultiple sclerosisTumor necrosis factoraCategoriesCáncer y tumoresEsclerosis múltiple
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