Immunohistochemical techniques in prion diseases

I. Gonzalo-Pascual, N. Cuadrado-Corrales [REV NEUROL 2000;31:156-159] PMID: 12497464 DOI: OPEN ACCESS
Volumen 31 | Number 02 | Nº of views of the article 5.862 | Nº of PDF downloads 297 | Article publication date 16/07/2000
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ABSTRACT Artículo en español English version
The prion diseases are characterized by showing a broad spectrum of phenotypes with different clinical and neuropathological presentations. Detection of the prion protein is the marker used as a tool for making the definite diagnosis in these neurodegenerative diseases. Its presence may be detected by immunohistochemical and biochemical techniques. On immunohistochemical studies the prion protein shows three types of staining: as plaques of PrP-amyloid, perivacuolar and diffuse-synaptic. KeywordsImmunohistochemistryPrion diseasesPrion protein CategoriesInfecciones
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