Original

Seizures and epileptic syndromes in the newborn. Forms of presentation, protocol for investigation and treatment

J. Campistol [REV NEUROL 2000;31:624-631] PMID: 12497367 DOI: https://doi.org/10.33588/rn.3107.2000320

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Volumen 31 | Number 07 | Nº of views of the article 6.420 | Nº of PDF downloads 1.897 | Article publication date 01/10/2000

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ABSTRACT

OBJECTIVES. To review the different forms of presentation of convulsions and epilepsies in the newborn, and to establish a protocol for diagnosis and treatment.

PATIENTS AND METHODS To achieve this we reviewed the literature and our own series over the past 15 years of 179 newborn babies with convulsions. RESULTS and

CONCLUSIONS We present the results of the etiological analysis of neonatal convulsions. Then we discuss a protocol for diagnosis and treatment of this condition, with particular emphasis on diagnostic methods according to their complexity. The different therapeutic options are considered using a protocol for treatment that starts with the use of phenobarbital, pyridoxine, biotin, folinic acid, intravenous sodium valproate, diphenylhydantoin, clonazepam, lidocaine + phenobarbital and if the convulsions persist thipentone. Finally, we analyze the duration of treatment and emphasise that after discharge from the unit, only convulsions persisting after the neonatal period or accompanied by severe electroencephalographic changes should be treated. Finally we evaluate the high morbi-mortality (48% and 20% respectively) of the neonatal convulsions seen in our series. This is mainly due to the fact that the population studied corresponded to a tertiary level hospital covering a large area with conditions of risk. CategoriesEpilepsias y síndromes epilépticos

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Original

Seizures and epileptic syndromes in the newborn. Forms of presentation, protocol for investigation and treatment