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Corrected cerebrospinal fluid manometry by measurement of the density and its relation with its biochemical composition

H. Miranda, R.G. Reymundo-Ponce [REV NEUROL 2003;36:26-32] PMID: 12577209 DOI: https://doi.org/10.33588/rn.3601.2001420

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Volumen 36 | Number 01 | Nº of views of the article 13.982 | Nº of PDF downloads 285 | Article publication date 01/01/2003

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ABSTRACT

INTRODUCTION and AIMS. We question the suitability of the usual methods for taking the pressure of cerebrospinal fluid (CSF). We suspect that the composition of CSF and, in consequence, its density have an important effect on its manometric value. MATERIAL AND METHODS. We obtained 322 CSF samples, with known cytological and biochemical composition, density and manometric values. We corrected the manometric measurements and, for each case, we calculated the exact pressure exerted by the column of CSF from its density, which was already known. The working variable was set as the manometric error (ME) that resulted from: Abs (calculated pressure of the column of CSF from its density – manometry) (absolute value of the difference).

RESULTS It was found that protein concentration levels in CSF had an important effect on the ME of the CSF, especially in values above 150 mg/cm3, and this result is extrapolated from our ad hoc mathematical model: corrected manometry (mmH2O) = manometry (mmH2O) + [cerebrospinal fluid protein (mg/cm3) / 50] – 2. CONCLUSION. This model proved to be a suitable predictor of ME in our sample, with a= 0.005. KeywordsCerebrospinal fluid Density Lumbar puncture CategoriesInfecciones

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Original

Corrected cerebrospinal fluid manometry by measurement of the density and its relation with its biochemical composition